Description
This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. [Isoform 2]: Receptor for calcitonin but is unable to couple to G proteins and activate adenylyl cyclase (PubMed: 7476993). Does not undergo receptor internalization following ligand binding (PubMed: 7476993)